C.I. Oxidation Base 2
4-Amino diphenylamine
CAS: 101-54-2
Molecular Formula: C12H12N2
C.I. Oxidation Base 2 - Names and Identifiers
C.I. Oxidation Base 2 - Physico-chemical Properties
| Molecular Formula | C12H12N2 |
| Molar Mass | 184.24 |
| Density | 1.09 |
| Melting Point | 69 °C |
| Boling Point | 354 °C |
| Flash Point | 193°C |
| Water Solubility | Soluble in water at 20°C 0.6g/L. Soluble in (10 mg/mL) ethanol. |
| Solubility | ethanol: soluble10mg/mL, clear, very dark red (Violet to brown to black solution) |
| Vapor Presure | 1 hPa |
| Appearance | Form Liquid, color Clear |
| Color | Clear |
| BRN | 908935 |
| pKa | 5.20±0.10(Predicted) |
| PH | 8.9 (0.5g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, plastics. |
| Refractive Index | 1.6266 (estimate) |
| Physical and Chemical Properties | Gray needle crystal. melting point 72 ℃ boiling point 354 ℃ solubility soluble in organic solvents such as ethanol, ether, can also be soluble in acid, alkali solution, slightly soluble in water. |
| Use | Intermediates for dyes and auxiliaries |
C.I. Oxidation Base 2 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R43 - May cause sensitization by skin contact R42/43 - May cause sensitization by inhalation and skin contact. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/22 - Harmful by inhalation and if swallowed. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S60 - This material and its container must be disposed of as hazardous waste. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN3077 |
| WGK Germany | 3 |
| RTECS | ST3150000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29215990 |
| Hazard Note | Irritant |
| Hazard Class | 9 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 464 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
C.I. Oxidation Base 2 - Upstream Downstream Industry
C.I. Oxidation Base 2 - Nature
Open Data Verified Data
gray needle crystal. Melting Point 72 °c. Boiling point 354 °c. Soluble in organic solvents such as ethanol, ether, soluble in acid, alkali solution, slightly soluble in water. It is easy to oxidize and change color in air.
Last Update：2024-01-02 23:10:35
C.I. Oxidation Base 2 - Preparation Method
Open Data Verified Data
- with P-nitrochlorobenzene and aniline in N-formyl aniline and potassium carbonate in the presence of direct condensation reaction, get 4 nitrodiphenylamine, after neutralization, water washing, and then sulfide alkali reduction (or hydrogenation reduction) water washing and distillation to obtain the finished product.
- with diphenylamine as raw material, after nitrosation in the organic solvent, to get the nitrosodiphenylamine. After the sulfide alkali reduction, to obtain the finished product.
Last Update：2022-01-01 10:52:47
C.I. Oxidation Base 2 - Use
Open Data Verified Data
dye and rubber auxiliary intermediate, used in the synthesis of amine antioxidant, such as antioxidant 4010, 4010Na, 4020, etc.
Last Update：2022-01-01 10:52:47
C.I. Oxidation Base 2 - Safety
Open Data Verified Data
- toxic. Can be absorbed through the skin caused by poisoning, the pathological phenomenon similar to aniline. The production site should be well ventilated and the equipment should be closed. Operators should wear protective equipment to avoid direct contact with the human body.
- sealed in iron drum, 200kg net weight per drum. Storage to fire, sun protection, moisture. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:52:48
C.I. Oxidation Base 2 - Reference Information
| Color index | 37240 |
| LogP | 1.82 at 20℃ and pH7 |
| dissociation constant | 5.45-5.47 at 20 ℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | intermediates for dyes and auxiliaries dye intermediates. Mainly used in the manufacture of antioxidant 4010NA,4020 and 668 and other important antioxidant; The manufacture of blue salt RT, acid red GR, disperse Yellow GFL and so on. redox indicator (oxidized red, reduced colorless). Dye Intermediates. Drug. Photographs were taken. Print, coat dye. |
| production methods | the production routes adopted at home and abroad are 4-nitrodiphenyl gum reduction method and 4-nitrosodiphenylamine reduction method. The former is divided into aniline and formamide method according to the raw materials used. And 4-nitrosodiphenylamine method, due to the diphenyl gum as raw material, also known as diphenylamine method. In addition, there is a method of reducing soap yellow. 1. Aniline process 4-nitrochlorobenzene was condensed with aniline (molar ratio 1:1.78) in the presence of copper catalyst (such as copper oxide and acid binding agent potassium carbonate) at 170-215 °c for 14h to give 4-nitrodiphenylamine, the yield was 90.6% based on p-nitrochlorobenzene. Raw material consumption quota: P-nitrochlorobenzene 1100kg/t, aniline 820kg/t, formic acid 500kg/t, potassium carbonate 650kg/t, sulfide alkali 1950kg/t. 2. Formyl aniline method formic acid and aniline condensation formyl aniline, and then with P-nitrochlorobenzene (formyl aniline dosage than the theoretical excess of 0%-100%), in the presence of acid binding agent potassium carbonate, at 120-195 ℃ reaction, 4-nitrodiphenylamine was obtained. The 4-nitrodiphenylamine obtained by the above two methods can be reduced by sulfide alkali or hydrogenation, or can be electrochemically reduced at 20-50 ° C. With a yield of 96%. 3.4-nitrosodiphenylamine method diphenylamine in the presence of acid, nitrosation with nitrite in solvent to obtain N-nitrosodiphenylamine, and then carried out translocation and rearrangement with anhydrous hydrogen chloride to obtain 4-nitrosodiphenylamine, the yield is 98%-99%. The temperature of nitrosation, translocation and rearrangement was 17-30 ℃. 4-nitrosodiphenylamine can be reduced at 50-100 ° C. With a sulfide base at atmospheric pressure, or it can be reduced by catalytic hydrogenation. In recent years, the research and development of hydrogenation reduction with nickel as Catalyst, the yield can reach 97%-98%. 4-nitrosodiphenylamine can also be obtained by electrochemical reduction in the yield of 96%. 4. Soap yellow Reduction Method: Add 55L of water, 23kg of 50% sodium sulfide and 6.6kg of sulfur into the reaction kettle, heat to boiling with stirring to dissolve all the materials, and then add 280L of water, 42.4 100% soap yellow, closed reactor, heated to 135 degrees Celsius, hot pressing 5H. After cooling to room temperature, filtered and rinsed with clean water until the filtrate was not yellow, 100% 4-aminodiphenylamine 19.9 was obtained. The yield was 90%. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 464 mg/kg; Oral-mouse LD50: 464 mg/kg |
| stimulation data | eyes-rabbits 100 mg/24 h moderate |
| flammability hazard characteristics | open flame flammable; Thermally decomposed toxic nitrogen oxide gas |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| extinguishing agent | sand and water |
| spontaneous combustion temperature | >500°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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View History
C.I. Oxidation Base 2
ZIRCONIUM AA SINGLE ELEMENT STANDARD
LANSOPRAZOLE USP(CRM STANDARD)
TRIETHYLENE GLYCOL DIACRYLATE
C.I. Oxidation Base 7
ZIRCONIUM AA SINGLE ELEMENT STANDARD
LANSOPRAZOLE USP(CRM STANDARD)
TRIETHYLENE GLYCOL DIACRYLATE
C.I. Oxidation Base 7
Raw Materials for C.I. Oxidation Base 2
Downstream Products for C.I. Oxidation Base 2